Systemic Scleroderma
|
0.500 |
PosttranslationalModification
|
disease |
BEFREE |
A higher level of methylation of GATA3 or STAT4 (Th2- and Th1-specific transcription factor genes, respectively) was observed in dcSSc.
|
31789272 |
2019 |
Systemic Scleroderma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways.
|
31672989 |
2019 |
Systemic Scleroderma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases.
|
30573655 |
2019 |
Systemic Scleroderma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Gene-level association analysis of systemic sclerosis: A comparison of African-Americans and White populations.
|
29293537 |
2018 |
Systemic Scleroderma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Among these genes, IRF5, STAT4, and CD247 were replicated most frequently while SNPs rs35677470 in DNASE1L3, rs5029939 in TNFAIP3, and rs7574685 in STAT4 have the strongest associations with SSc.
|
28526340 |
2017 |
Systemic Scleroderma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Since IRF5, STAT4, and IRAK1 are important regulatory factors in the control of innate immune responses and CTGF is involved in the synthesis of extracellular matrix, these results suggest a role of the innate immunity and matrix compounds in the pathogenesis of PF in SSc.
|
28434122 |
2017 |
Systemic Scleroderma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Transethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis.
|
28314753 |
2017 |
Systemic Scleroderma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
For STAT4 polymorphism, we observed a statistically significant positive association between risk factor T allele carriers and SSc susceptibility (OR = 1.37, 95% CI = 1.27-1.48, P < 0.00001) in the overall population.
|
26712637 |
2016 |
Systemic Scleroderma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis.
|
24387989 |
2014 |
Systemic Scleroderma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The results were consistent with previous reports in other ethnic populations in supporting the notion that polymorphisms of STAT4 may play an important role in susceptibility to SSc.
|
23755762 |
2013 |
Systemic Scleroderma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.
|
23740937 |
2013 |
Systemic Scleroderma
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.
|
23740937 |
2013 |
Systemic Scleroderma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Five single nucleotide polymorphisms, IRF5 (rs10488631, rs12537284, rs4728142), STAT4 (rs3821236), CD247 (rs2056626) reached genome-wide significance in the SSc-GWAS and were examined in the current study.
|
22440820 |
2012 |
Systemic Scleroderma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We examined the relationship between five gene polymorphisms [cytotoxic T lymphocyte associated antigen 4 (CTLA-4) -1722T/C, CTLA-4 -318C/T, CTLA-4 +49A/G, angiotensin-converting enzyme I/D, STAT-4 rs7574865] and susceptibility to SSc.
|
22173230 |
2012 |
Systemic Scleroderma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.
|
21779181 |
2011 |
Systemic Scleroderma
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.
|
21779181 |
2011 |
Systemic Scleroderma
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis.
|
21750679 |
2011 |
Systemic Scleroderma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis.
|
21750679 |
2011 |
Systemic Scleroderma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus.
|
20383147 |
2010 |
Systemic Scleroderma
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus.
|
20383147 |
2010 |
Systemic Scleroderma
|
0.500 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus.
|
20383147 |
2010 |
Systemic Scleroderma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Furthermore, gene-gene interaction studies suggest that IRF5, STAT4, and BANK1 as well as TBX21 and STAT4 interact with regard to scleroderma susceptibility.
|
20090527 |
2010 |
Systemic Scleroderma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Multiple SNPs in TBX21 and STAT4 were found to be associated with SSc.
|
19950257 |
2009 |
Systemic Scleroderma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The BANK1, IRF5, and STAT4 risk alleles displayed a multiplicatively increased risk of dcSSc of 1.43-fold.
|
19877059 |
2009 |
Systemic Scleroderma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Genetic studies in the systemic sclerosis (SSc), an autoimmune disease that clinically manifests with dermal and internal organ fibrosis and small vessel vasculopathy, have identified multiple susceptibility genes including HLA-class II, PTPN22, IRF5, and STAT4 which have also been associated with other autoimmune diseases, such as systemic lupus erythematosus (SLE).
|
19796918 |
2010 |